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Most prescription obesity drugs have not proven to be effective for long-term weight control. Many people who use them eventually gain the weight back, and they run the risk of serious side-effects while they’re on them.

A prescription drug combination made up of Phentermine and Fenfluramine, known as Phen-Fen, was removed from the market after several people developed valvular heart problems while using them. Fortunately, using Phentermine alone doesn’t appear to cause heart problems.

Now, researchers are looking at a combination of Phentermine and a migraine drug called Topiramate for weight loss. Does it work – and is it safe?

Topiramate and Phentermine for Weight Loss: Does It Work?

According to a study published in the journal Lancet, combining Phentermine with Topiramate significantly boosted weight loss in a group of 2,487 obese people. When these participants took a once-a-day dose combination of these two medications, they lost considerably more weight than the placebo group.

At the lower dose used in the study, participants lost 7.8% of their body weight vs. 1.2 percent for the placebo. The higher dose group lost almost 10% of their body weight.

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